N.N. Burov presents in his paper a theory of Supra-Molecular Detoxification during anesthesia. Burov's theory is based on a molecular model of Xenon anesthesia as formulated by L. Pauling in 1961.
Title: Pathogenic Basis of Xenon Inhalation Therapy
Author: N. N. Burov, Department of Anesthesiology and Reanimatology, Moscow
The mechanisms of Xenon anesthesia at the molecular level was first described by Nobel laureate L. Pauling in 1961. Pauling applied X-ray diffraction method and formulated a molecular theory of anesthesia based on clathrate formations. His argument was as follows.
The human brain consists of approximately 78% water, 10% protein and 12% fat. Which component will Xe react with when it enters the bloodstream through the airways? The answer is obvious; Xe will react with water molecules. However, Xe does not dissolve in water (K =0.085). Xenon, as an external or alien agent to water, will form a compound of xenon hydrate (Xe.6 (H2O). Xenon hydrate is an unstable compound, in which Xe is the 'guest', and water molecules are the 'mistress', who takes the guest into her arms according to the laws of intermolecular attraction (Van der Waals forces). As a result of this connection a dipole is formed in each molecule. Dipoles of molecules attract one another and molecules become interconnected. That leads to the formation of clusters of water molecules, which encage xenon. Clathrate clusters (crystals) enter into spatial frequency-field interactions with receptors and sections of the nerve cell membrane, capture the electrical chains of cell proteins, increase its permeability, reduce metabolism, interfere with electrical vibrations (impedance), and create inhibition of the bioelectric activity of the brain, which is the onset of anesthesia. The state of narcosis has been confirmed by many clinical and EEG studies.
However, L. Pauling was a chemist, not an anesthetist. He did not realize that xenon anesthesia had a powerful therapeutic effect. The therapeutic effect of xenon was discovered by Russian anesthetists at the turn of the 21st century.
What is the therapeutic effect of xenon anesthesia?
As L. Pauling states, clathrate cluster is an unstable compound that quickly disintegrates as anesthetic concentration decreases and the temperature increases. All other anesthetics have the ability to form clathrates but they differ from one another and from xenon by their chemical aggressiveness and frequency field activity.
The structured water of the brain tissue has a remarkable property that allows her to protect the nerve cell from a direct entry of alien agents that are potentially aggressive and with a high vibration frequency. Water molecules surrounding the Xe molecule (Xe molecule is practically encaged by water molecules) form together xenon hydrate. Xenon hydrate is chemically nonaggressive with wave vibration close to the physiological one. It has a loose structure containing 8 chambers. Two chambers contain 20 water molecules and 6 chambers are filled with 24 water molecules forming geometric shapes (crystals). Small chambers are filled with xenon, large chambers can be filled with molecules of large sizes, or other anesthetics, or metabolites.
In order to complement Pauling's molecular theory of anesthesia, and drawing on more than 19 years of clinical experience with xenon anesthesia, we argue that the process of clathrate formation is an evolutionary established process in nature, which performs a protective function in a biological object. Molecules of endogenously structured water have a crucial role in this process.
Xe hydrates (clathrates) and Xe-free 'water associates' are capable of taking various toxic metabolic products, free radicals, and other toxins into their free cavities or chambers according to the law of intermolecular interaction (Van der Waals) and have therefore a general detoxifying effect at the molecular level.
Detoxifying effect of xenon at the molecular level explains a subjective feeling of relief, freshness and good mood and an increase in working capacity by patients exiting xenon anesthesia, as documented by numerous clinical observations. Bedridden cancer patients show an increase in physical activity after inhaling xenon. Among the observed effects of the 'Russian bath', as some call xenon inhalation, belong for example a feeling of newly obtained health, vitality and mood improvements.
This process of a quite peculiar cleansing of the body we call supramolecular detoxification of the clathrate type, when alien agents in the form of frequency field radiation are eliminated by ionic molecular interactions of structured water in a huge molecular field, for a purpose of protecting cells from damaging effects of these agents. In other words, we believe that clathrate formation is an evolutionary developed natural mechanism of a peculiar protection of a biological cell from actions of a chemical agent. We assume that this is the 'mystery' of the mysterious xenon anesthesia. Xenon essentially mobilizes the entire mechanism of clathrates and water associates not only for anesthesia, but also for maintaining homeostasis, as a necessary living condition of a biological substrate, and that through supramolecular detoxification and absorption of metabolism products.
The cleansing process begins, in our opinion, immediately during anesthesia, when the 'density' of Xe hydrates (clathrates) as well as the number of 'free rooms/chambers' increases in the bodily tissue. The cleansing process continues also after the use of anesthesia. Due to the presence of a significant 'area' of post-xenon water associates (empty/vacated chambers), xenon anesthesia continues to have a purifying effect for another 1 to 3 days after the Russian bath (V.V. Dovgush, 2007).